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pssA [2019-06-18 09:14:23]
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pssA [2019-06-18 09:14:23]

phosphatidylserine synthase
locus
BSU02270
pI
7.88
mw
19.47 kDa
protein length
177 aa Sequence Blast
gene length
534 bp Sequence Blast
function
biosynthesis of phospholipids
product
phosphatidylserine synthase
essential
no
ec
2.7.8.8
synonyms
pss
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    247,744 → 248,277

    The protein

    Catalyzed reaction/ biological activity

  • CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine (according to Swiss-Prot)

    • Protein family

  • CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane at the septum [Pubmed|15743965]

    • Expression and Regulation

    Operons

    genes
    [gene|27FB777AEBCC794A5A768C7FE7D8374BCEA75913|ybfK]-[gene|DE49797486CEC172F912D26A6BF2223190BF5DAD|pssA]-[gene|B2C089DCE51CA0CB11947FCD6F4EFAFF66269829|ybfM]-[gene|F34915697F3EF05E6A683055F46346C73F25CAFC|psd]
    description
    [Pubmed|22383849,14762009]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|14762009], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX]: sigma factor, [Pubmed|14762009], in [regulon|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX regulon]
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    Biological materials

    Mutant

  • BKE02270 (Δ[gene|DE49797486CEC172F912D26A6BF2223190BF5DAD|pssA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02270 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAGTGTAACCAAACCTCC, downstream forward: _UP4_GCAGAAAACCTGGAGTCTGG
  • BKK02270 (Δ[gene|DE49797486CEC172F912D26A6BF2223190BF5DAD|pssA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02270 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAGTGTAACCAAACCTCC, downstream forward: _UP4_GCAGAAAACCTGGAGTCTGG

    • References

    Reviews

  • 9370336

    • Original publications

  • 14762009,18820022,9422599,8829529,15743965,28376879